Postdoctoral researcher and/or a doctoral student in biological nanosciences, Jyväskylä, Finland

We are seeking a highly motivated individual to investigate the differences between enzyme activity in solution and in crystals. Differences between reaction rates and spectral signatures of intermediates will be rationalised with molecular dynamics simulations to ultimately train a computational model with which the effects of crystal packing on enzyme catalysis can be predicted. The experimental work includes time-resolved laser spectroscopy, biochemical assays, X-ray crystallography, and Serial Femtosecond Crystallography (SFX). The computational work includes large-scale molecule dynamics simulations of enzymes in both solution and crystals environments, as well as hybrid quantum mechanics/molecular mechanics (QM/MM) based reaction path optimizations.

The successful candidate will join an international team of researchers at the Department of Biological and Environmental Science or at the Department of Chemistry, University of Jyväskylä. The group of Janne Ihalainen studies physical chemical phenomena of proteins. The group of Gerrit Groenhof focusses on the development and application of atomistic simulation techniques for chemical reactions in biomolecular systems.

You are the person we are looking for if you have a Doctoral/Master’s degree, or be about to obtain a Doctoral/Master’s degree, in biochemistry, biophysics, physical chemistry or physics, and if you have a strong interest in laser spectroscopy, functional studies of proteins (in particular enzymes), biophysics, and/or biochemistry. Experience in laser spectroscopy, X-ray crystallography, or in enzyme catalysis is therefore considered an advantage. You are expected to have excellent written and oral communication skills and to be able to work independently in the laboratory.

The duties, qualification requirements and language skills of a postdoctoral researcher and a doctoral student are stipulated by the University of Jyväskylä Regulations and language skills guidelines. A good command of English is required and a proficiency to teach in English will be considered beneficial. The PhD/MSc degree required for the position must have been completed before starting the position.

How to apply?

The application documents that should be included in PDF format:

  1. A two-page long Curriculum vitae, composed according to good scientific practice and considering the template for researcher´s curriculum vitae by The Finnish Advisory Board on Research Integrity and including contact information of two academics who can provide reference letters
  2. Cover letter including a statement of research interests.
  3. A numbered list of publications, if any
  4. Relevant certificates / diplomas (or date of completion the PhD)

Applicants are kindly asked to submit their applications using the online application form (https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=12&id=000010301&lang=fi) by January 22nd, 2021.

For further details, please contact: Professor Janne Ihalainen for the experimental aspects of the project and Professor Gerrit Groenhof for the computational aspects.