Postdoc Position in Single Cell Imaging at the Rosalind Franklin Institute, Harwell Campus, Didcot, England

The project focuses on the development of new mass spectrometric imaging instrumentation from ion source technology through mass spectrometric analysers to new workflows for data analysis and interpretation. The new ionisation modalities including laser desorption methods and secondary ion mass spectrometry employing multiply charged cluster projectiles will enable spatial resolutions required for true single cell resolution. The postholder will be expected to work on biological aspects of the development and demonstration of cellular resolution MS imaging, including culturing cells and organoids and preparing both animal and human tissues for analysis. The work includes alternative modalities of imaging, for example histological imaging, immunofluorescence, confocal microscopy, imaging mass cytometry and single cell transcriptomics. While the post holder is not expected to participate in instrument building, good technical skills are desirable for using experimental research instrumentation.


Deadline for application: 26 March 2023