Post-doctoral fellow for the development imaging of single molecules in depth with the ModLoc approach at the Institut des Sciences Moléculaires d'Orsay, Gif-sur-Yvette, France

The Nanobio team is developing new single molecule localisation microscopy methods to push back the limits of these observations in terms of both acquisition speed and depth of observation. In particular, the team has demonstrated the benefits of introducing structured excitation for the observation of complex samples such as tissue or organoids. The aim of this post is to develop a new implementation of this technique called ModLoc for modulated localization. The aim is to set up a new instrument that will improve stability, resolution, acquisition speed and observation volume. In particular, the sample excitation and fluorescence detection methods will be rethought, then validated on various deep biological applications (several tens of microns). This project will be carried out as part of the EIC Nanoscan, which includes Politechnico di Milano, the CNS, Laserlab and abbelight, and will benefit in particular from a new generation of patented optical chips for generating structured excitation.

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Application Deadline : 18 March 2024